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In cell and animal studies, KPV directly inhibits NF-kB and p38 MAPK signaling, lowering pro-inflammatory cytokines like TNF-alpha, IL-1beta, and IL-6

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The continuous use approach represents traditional treatment strategy where daily GHK-Cu application continues indefinitely or until goals achieved, then potentially reduces to maintenance frequency (every other day or few times weekly) rather than complete discontinuation

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