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When To See A Doctor Book an appointment if you have symptoms suggestive of deficiency (persistent fatigue, pale or jaundiced skin, mouth soreness, numbness or tingling, balance changes, memory or mood issues), especially if you’re vegan/vegetarian without fortified foods, over 50, post–bariatric surgery, or on long-term metformin or acid-suppressing medicines

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A 2025 rat study in Frontiers in Physiology by Pham and colleagues used a type 2 diabetes model