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Both GLP-1R activation (which can reduce fluid intake through appetite suppression) and GCGR activation (which may mildly increase renal water loss through osmotic effects of hepatic glucose production) can contribute to mild dehydration if fluid intake is not consciously maintained

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Analytical validation guidance treats identity, purity, assay, and impurity testing as distinct analytical purposes, so a single number should not be read as the whole documentation story [12]