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The rationale is that glucagon also increases energy expenditure and promotes hepatic fat mobilization, so a molecule that combines glucagon’s metabolic-rate effect with GLP-1/GIP’s appetite-and-glucose control can, in principle, drive weight loss from both sides of the energy-balance equation at once

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Research indicates that replenishing B12 levels in individuals with a deficiency can be effectively achieved through oral vitamin B12 administration or intramuscular injections