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Following this discovery, several studies investigated the peptide’s impact on the extracellular matrix and related physiological functions, including: Another study, “ In vivo stimulation of connective tissue accumulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu 2+ in rat experimental wounds ,” demonstrated that GHK-Cu increased collagen, protein, DNA, and glycosaminoglycan contents in the connective tissue of experimental wounds