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[12] Importantly, however, none of these laboratory findings are specific to bone sarcomas, meaning that elevations in these lab values are associated with many other conditions as well as sarcoma, and thus cannot be relied upon to conclusively diagnose sarcoma

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However, the remarkedly increased citrate synthase and lactate dehydrogenase activities in patients with COPD suggested a metabolic adaptation in both mitochondrial glycolytic and oxidative capacities (46)