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It should be noted that while an increase in the androgen receptor and testosterone are pro-androgenic, an increase in SHBG is anti-androgenic, and the researchers took a measurement called the “free androgen index” (FAI), to assess whether a net positive or a net negative result occurred

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MT-1 is more selective for the MC1R receptor, while MT-2 has broader melanocortin receptor activity in research models

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