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Both homocysteine and its reactive metabolite, homocysteine thiolactone, can damage blood vessels and other tissues, and even levels in the upper “normal” range are associated with increased all‑cause mortality Genetic variants can increase the risk of high homocysteine, depending on your intake of B vitamins and choline

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Melanocytes import cystine through the xCT SLC7A11 transporter (Chintala et al., 2005), and cystine is then reduced to cysteine by Cystine reductase