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Since mouse microbiome profiles often highly correlate with body weight and fat composition, this study was designed to test whether the cecal microbiomes of DIO mice treated with NNMTi and LD were comparable to the microbiomes of age-matched lean counterparts and distinct from microbiomes of DIO mice maintained on a high-fat Western diet (WD) or subjected to LD switch alone

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Unlike many weight loss compounds that work through appetite suppression or metabolic stimulation, AOD-9604 directly targets fat tissue at the receptor level, making it one of the most precise fat reduction tools available in peptide therapy