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Hypothyroidism contributes to OxS through an inefficient antioxidant defence system, opposite to hyperthyroidism, where increased ROS production promotes OxS and oxidative damage of thyroid cells ( Figure 1 ) ( 5.1 Thyroid dysfunctions and OxS 5.1.1 Hypothyroidism Even in its subclinical form, hypothyroidism reduces antioxidant system activity, which promotes OxS, causing oxidative damage and altered lipid metabolism in thyroid cells (84)

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In order to be successfully synthesized in ER, the chaperone GRP78 is induced and activated to promote the refolding process of misfolded proteins (Yoboue et al., 2017) , (Wei et al., 2012)