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In agreement with these reports, Doxorubicin induced senescence in IMR90 in vitro , evident by elevated SA-β-GAL activity, expression of p16 ink4a , and the early and late SASP factors IL-1α and IL-6 (Orjalo et al., 2009), respectively (Fig

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DR stems from a complex pathology involving oxidative stress, inflammatory lesions, and the polyol pathway

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