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NAD+ enhancement has been shown to reduce neuroinflammation and improve cognition in models of neurodegeneration [3]

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The ACADSB encoded enzyme prefers the branched-chain acyl-CoA, 2-methylbutryl-CoA, which is a product of the catabolism of isoleucine, but is also functional on the short straight-chain acyl-CoAs, butyryl-CoA and hexanoyl-CoA