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[DOI] [PubMed] [Google Scholar] 154.Hu C, Lancaster CS, Zuo Z, Hu S, Chen Z, Rubnitz JE, Baker SD, Sparreboom A

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For the treatment of depression, osteoarthritis, and liver conditions, SAM has been studied when taken orally or intravenously.[6] SAM may act as a methyl donor in the metabolic processes that control lipid homeostasis, DNA stability, gene expression, and neurotransmitter release, which may account for the benefits it confers.[7][8][9] Choline Choline is an essential nutrient required for optimal functioning of various tissues including the liver, muscles, and brain.[15] Since choline breaks down fat as an energy source, choline supplementation caused rapid fat and weight loss in female athletes.[16] Only small amounts of choline are synthesized by the human body, necessitating its intake from external sources