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Footnotes Edited by: Dawei Chen, University of Kiel, Germany Reviewed by: Eveljn Scarian, University of Pavia, Italy Hong Cheng, Yangzhou University, China Author contributions EK: Conceptualization, Data curation, Formal Analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review and editing

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In the tissues, CO 2 enters the erythrocyte by diffusion, where it is hydrated with the help of carbonic anhydrase