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Their exceptional chemical stability allows environmental persistence exceeding two decades, leading to progressive bioaccumulation through food webs and preferential storage in lipid-rich tissues ( Human exposure to these compounds occurs through multiple pathways—ingestion, inhalation, and dermal absorption–with subsequent accumulation in adipose tissue, hepatic systems, and critically, reproductive organs ( 1.2 Key research challenges Despite substantial advances in understanding individual EED toxicity profiles, several fundamental knowledge gaps continue to impede comprehensive risk assessment: Complex Mixture Effects Remain Poorly Understood While toxicological studies have extensively characterized individual EED effects, real-world human exposure invariably involves simultaneous contact with multiple compounds