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More recently Pfizer has reported development of a humanized GHR monoclonal antagonist antibody (RN172), which blocked GH signaling in vitro and reduced IGF1 production in monkeys following a single-intravenous injection

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MOTS-c has been proposed as an 'exercise mimetic' in the sense that it can replicate specific downstream metabolic signatures of exercise—though it cannot replicate the cardiovascular, bone density, or psychological effects of actual physical activity

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